Standardization of Polyherbal Formulations for Drug Analysis

Standardization of Polyherbal Formulations for Drug Analysis Standardization of polyherbal formulations is essential in order to assess the quality of drugs, based on the concentration of their active principles (markers or standards). As Mentat tablet (MT), a herbal formulation consist of natural multi-ingredient formula with active constituents responsible for treatment of neurological disorder and improvement of mental health, therefore it is worthwhile to take it as a model for standardization of polyherbal formulation. In this work, an ultra-performance liquid chromatography electrospray ionization tandem mass spectrometry method has been developed and validated for simultaneous quantification of 28 major bioactive constituents. Multiple-reaction monitoring scanning was employed for quantification in positive and negative mode. The analysis was accomplished on Waters AQUITY UPLC BEH C18 column with linear gradient elution of acetonitrile 0.1% formic acid with water 0.1% formic acid solutions at a flow rate of 0.3 mL/min. The comparative a nalysis of samples was carried out by hierarchical cluster analysis and principle component analysis. The proposed method was applied to analyze 4 different batches of marketed formulation with acceptable linearity (r2, 0.9984-0.9999), precision, stability and recovery (RSD ≠¤ 3.74 %), evaluated under optimum conditions. The developed method is capable of controlling quality of polyherbal formulations having similar markers and herbs. Herbal medicines (HMs) refer to one herb or complex mixtures, which usually contains hundreds of chemically different components. Their curative effects are principally based on the synergic effect of their multi-targeting and multi-ingredient preparations [1, 2]. Consequently, quality control becomes a troublesome issue for crude drugs and their medical preparations. Therefore, the method that employs pharmacologically active components to evaluate the quality and authenticity of the complex preparations is confronted with severe challenges and better analytical strategies to assure their efficacy, safety, and consistency are in great demand [3]. Moreover, the chemical compounds in the poly herbs in HMs products may vary depending on harvest seasons, plant origins, drying processes and other factors. Thus, it seems to be necessary to determine most of the phytochemical constituents of herbal products in order to ensure the reliability and repeatability of pharmacological and clinical research, to perceive their bioactivities and eventual side effects of active compounds and to enhance product quality control [4, 5]. Currently, selection of a single or a few specific components from a certain herbal medicine as markers for quality assessment is a widely applied strategy. However, it cannot afford sufficient quantitative information for the other medicinal compositions and cannot accurately reflect the quality of HMs products. All the HMs compositions play important roles in the therapeutic effects. Therefore, selecting multiple constituents from different medicinal herbs as evaluation markers has been gradually applied for the quality control of HMs [6, 7]. Mentat tablets (MT, commercial product) is a polyherbal medication with each tablet composed of extracts (136 mg of Bacopa monnieri, 70 mg of Centella asiatica, 52 mg of Withania somnifera, 52 mg of Evolvulus alsinoides, 52 mg of Nardostachys jatamansi, 50 mg of Valeriana wallichii, 50 mg of Embelica ribes, 50 mg of Prunus amygdalus, 42 mg of Acorus calamus, 36 mg of Tinospora cordifolia, 36 mg of Terminalia chebula, 36 mg of Emblica officinalis, 32 mg of Oroxylum indicum, 32 mg of Celastrus paniculatus) and powders (80 mg of Bacopa monnieri, 18 mg of Withania somnifera, 18 mg of Mucuna pruriens, 18 mg of Elettaria cardamomum, 18 mg of Terminalia arjuna, 18 mg of Anethum sowa, 18 mg of Ipomoea digitata, 14 mg of Zingiber officinale, 14 mg of Terminalia belerica, 14 mg of Myristica fragrans, 10 mg of Syzygium aromaticum). MT is a unique all-natural multi-ingredient formula that promotes brain health. It improves the mental quotient, memory span, concentration ability, stress threshold and exhibit significant anti-parkinsonian activity. MT also offers protection against convulsions, which is beneficial in insomnia with its sedative and tranquilizing effects [8-10]. There are various pharmaceutical manufacturers that produce herbal formulations with similar herbs combinations to treat various neurological disorders. Chemically, bacosides the saponin mixture of Bacopa monnieri and triterpenoid glycosides in Centella asiatica have been considered as the key active components. [11-14]. Phytochemical investigations show important classes of bioactive constituents in selected plants as in combination of MT that are responsible for the bioactivity [15-20]. Literature survey reveals that, analytical methods including thin layer chromatography (TLC) [21], high performance thin layer chromatography (HPTLC) [22, 23], liquid chromatography (LC) [6, 24, 25], liquid chromatography coupled with mass spectrometry (LC-MS) [26-29], nuclear magnetic resonance (NMR) [30] have been developed for the quantitative analysis of the bioactive constituents in HMs to assess the quality of the complex preparations. Natural alteration in preparation processes and climate affects the safety and batch-to-batch uniformity of HMs products. Highly sensitive analytical methods are thus required to identify ingredients and evaluate lot-to-lot consistence. To the best of our knowledge, there is no method have been reported for the simultaneous estimation of selected 28 multi-markers in herbals by UPLC-ESI-MS/MSand no such formulation approach has been explored on this important drug combination for quality consistency evaluation of this herbal preparation. Compared to conventional TLC, HPTLC, HPLC–UV method which will take a longer analysis time, UPLC-ESI-MS/MS method in multiple reaction monitoring (MRM), tandem MS scan mode offers detection effectively with more powerful approach, to rapidly quantify multi-ingredients in complex sample matrices due to its rapid separation power, low detection limit, high sensitivity, selectivity and specificity. The methods used or reported in literature only contained one or two compounds, without consideration of other active ingredients. This paper describes for the first time a simple, accurate and reliable UPLC-ESI-MS/MS method for the simultaneous determination of 28 bioactive multiple components from different polyherbs including: bacoside A (mixture of bacoside A3, bacopaside II, bacopaside X and bacopasaponin C), withanolide-A, withaferin-A, asiaticoside, madecassoside, jatrorrhizine, palmatine, magnoflorine, curcumin, gallic acid, protocatechuic acid, ferulic acid, caffeic acid, ellagic acid, rosamarinic acid, ursolic acid, catechin, apigenin, luteolin, quercetin, rutin, kaempferol-3-O-rutinoside, corilagin, chrysin and chlorogenic acid with single runtime of 10 min. The results indicated that the developed method is fast, sensitive and convenient to show the real quality of the polyherbal preparations. Therefore, this proposed method could be reliable and feasible for quality assessment of MT and all other herbal formulations manufactured by various pharmaceutical manufacturers with similar herbs combinations containing either these 28 markers or less. The method was also applied to analyze the multiple components in MT different batches from same manufacturer. Our results will facilitate the comprehensive quality control of MT and other similar related preparations. The quantitative results were further analyzed by multivariate statistical analysis i.e., hierarchical cluster analysis (HCA) and principle component analysis (PCA) to provide more information about the chemical differences and batch-to-batch uniformity.

Racism in Toni Morrisons Song of Solmon Essay -- Song of Solmon Essay

Racism in Toni Morrison's Song of Solmon Milkman is born on the day that Mr. Smith kills himself trying to fly; Milkman as a child wanted to fly until he found out that people could not. When he found, "that only birds and airplanes could fly&emdash;he lost all interest in himself" (9). The novel Song of Solomon is about an African American man nicknamed Milkman. This novel, by Nobel Prize winner Toni Morrison was first published in 1977, shows a great deal of the African American culture, and the discrimination within their culture at the time Song of Solomon takes place. In part one, the setting is in a North Carolina town in the 30's and 40's. Â   Part one introduces readers to not only Milkman, but also to his family and friends. His father holds power in the African American community because he has his own business and is ambitious. Milkman's mother is a center figure in the community simply because her father was the doctor. Milkman has a mysterious unmarried Aunt, with a single daughter and granddaughter. He also has a friend, Guitar who is a member of a group of seven African American men dedicated to keeping the 'ratio' between blacks and whites the same. Throughout the novel, Milkman gradually learns about his families past as well as forgotten pieces of his own childhood. Â   In part two, Milkman goes south to his father's hometown. He is looking for a fortune that his father and aunt had found long before. When he does not find the fortune he begins trying to find where it went. This takes him to where his great grandfather and mother originated. Milkman eventually is led to the town where he is a direct descendant of the town's legend, Solomon. It is in this town that Milkman finds himself and becomes his own m... ... lied for it, killed for it," (247). For her revenge, after all of the Butlers died Circe says "I want to see it all go, make sure it does go, and that nobody fixes it up. I brought the dogs in to make sure" (247). She allows everything they loved to be destroyed. Â   Morrison shows readers a side of American History rarely seen. She shows the deepness of prejudice and how many different ways it has effected people. While she does this she also tells a story of soul searching, Milkman tries to find himself among many people who are confused and ate up by hate and prejudice. In the end, he is able to find who he is and where he stands on all of the issues that are going on around him. When he gets this understanding Milkman retrieves, and achieves his childhood dream of flying. Works Cited Morrison, Toni. Song of Solomon. New York, Penguin Books USA Inc., 1987

An Influenced Life Essay

An Influenced Life As people grow and develop in their lives, many factors influence their trajectories. These factors manifest themselves in many ways, but some are more prominent than others. I believe that every person, depending the factors that influenced them most strongly, would place more importance on some factors than others. In other words, my essay will be different than other classmates, because I was raised differently than most of them and different things had impacts on my development. Individuals also probably think some are more important factors than others, and these viewpoints depend solely on their lives and their development thus far. My personal view is that some of the most important factors that influence an individual’s development are their innate temperament, the parents they are born to, the consequent family role they possess, the anxiety they bear in life, and the relationships they make – both forced and by their own volition. Read more: Essay explain how children and young people’s development is influenced by a range of personal factors. Although I believe these are some of the most important factors, they are by no means the only things that influence a persons’ development over time. Also worth noting is the fact that these all impact each other as well as singularly influencing an individual. When combined, many factors cause other factors and all influence a persons’ development trajectory. One of these influences is inborn, not decided by outside forces. Temperament is something every human is born with, and it is shown from the moment they start breathing. My sister and I, for example, have somewhat opposite temperaments. As a child I was very loud and loved to talk (which hasn’t changed), and my sister was much quieter and listened much better than I ever could. She was more patient from birth than I will ever be. This chasm between our personalities provides some definition for our life development. Her calm, quiet manner led to little misbehavior and consequent punishment. My quick, sarcastic temper led to much conflict with parents and occasionally teachers, and required containment. This put me in a different trajectory than my sister, as she became easy to deal with, and easy to please. My parents had to take a different approach with me, as my temperament led me to be harder to discipline, please, and control. The temperament of any individual greatly influences a person’s future life development. It influences the way a person reacts and relates to other people, the way they act alone and in company, and their view on the world. Parents are one of the influences I think most would agree impacts development most. Even people who had parents that were not present might agree that the absence itself influenced their life and development. The techniques parents use vary and are quite different from family to family, and occasionally even within families. Parenting impacts development and views of the world because they restrict or allow activities, and provide moral ideas and values in differing strengths, passing on much to their children. As we grow out of childhood, impressions of our parents from a young age remain with us and impact the way we live, act, and interpret others’ behaviors. The two spectrums for parenting styles measure how demanding a parent is, and how responsive a parent is. To me, these can make or break a child’s development. If either is too low, the child will have problems later in life, but if either is too high, there will also be consequences. High responsiveness may produce a needy, incapable adult, while low responsiveness will result in anxiety about love, and mattering. High demanding parenting may result in a high-strung, over-achieving stressed adult, while low demanding will produce an adult with little motivation and drive. Clearly, parenting impacts development and, if possible, should be controlled in order to help children develop correctly and well. As parents begin to treat children differently due to temperament, and children learn more about their parenting styles, the kids in the family begin to learn their roles in the family. These roles can range from simply the â€Å"quiet one† to â€Å"loud one,† or from â€Å"instigator† to â€Å"peace-maker.† Some of the roles can make children feel guilty, unworthy, or bad about themselves, while others make childr en feel proud, confident, and pleased. These differences start at a young age and continue through their lives, even into adulthood. This will also influence relationships and life plans, causing each person to have a different filter per say, which they view the world through. If an individual follows these family roles into adulthood, individuals follow whatever mold they were shaped into as a young person. This can obviously impact development in frightening ways. One can imagine a forty year-old still following his instilled role of a meek, rule-following, shy six year-old, or a twenty-one year-old still behaving as a reckless, authority defying teenager, but with much more damaging and dangerous rebellions. The types of anxiety that a person deals with on a frequent  basis derive from many sources. These factors come from both developmental sources and environmental sources. While environmental sources are inevitable and cannot be avoided, like natural disasters and wars, the developmental sources can be somewhat traced to other developmental factors. If a person carries too much anxiety, they can then begi n to develop harmful relationships and tendencies. Some anxieties that can hurt a persons’ development are worrying about trust, competence, and mattering. All three of these concerns can come from the way an individual is treated and affected by people close to them, and society as a whole, along with some of the traits they were born with. These main three concerns make or break relationships, another developmental factor. However, they also impact the way we develop in all strains of life, especially cognitive development. If someone has anxiety about not mattering or being competent, and this anxiety is reinforced by their relationships, they may truly begin to believe these things. This will begin to impact their work and productivity, starting to truly render them incompetent. Relationships also play a large role in development over time. Of all the factors discussed, I think this may be one of the most obvious, but also one of the most influential. Depending on the individual someone is relating to, and the impacts other developmental factors have on them too, relationships are the dynamic culmination of influences on human devel opment. Relationship models range from secure to insecure, and someone who forms insecure relationships is unlikely to trust anyone, and consequently bear even more anxiety than what led to the insecure relationship. I think relationships influence development because relationships give us friends, role models, and comfort. Relationships make life worth living, but if they are not healthy and secure relationships, the zeal for life may degrade. There are many factors that impact development in many different ways. These influences can have physical, social, cognitive, and emotional consequences, and help us to become the adults we do in life. They eventually all do interrelate and combine to influence each other and our development in many ways. This being said, it is crucial to development to have consistent, good, controlled factors. Although temperament cannot be controlled, parenting styles, family roles, and relationships can be objectively considered and helped, in order to ensure proper development and a productive, competent adult. If every child had these factors controlled  and watched, in order to help them develop the best they could, there would be much less anxiety, unhappiness, and idleness in our society.

The Lost World essays

The Lost World essays The Lost World was written by Michael Crichton. This book is the sequel to Jurassic Park. This is book takes place on the island Isla Sorna. It was a privately owned island on the west coast of Coast Rica by InGen. They are the biology company that made the dinosaurs and founded Jurassic Park. This island is where the first dinosaurs were born. Dr. Wu just came up with this new technology and they werent sure how it would turn out so they made all the original eggs on this island. Then once they got it right then they make the eggs on Isla Nublar. The main characters were Richard Levine, Ian Malcolm, Doctor Thorne, and Sarah Harding. Richard Levine made all of the other people get into this mess. He had discovered that the Coast Rican government were burying strange dead animals that washed up on the coast. He went down there and send a piece back to Ian Malcolm. Malcolm brought it to a zoo and they said that it was tagged and that it was something that they had never seen before. At that moment Malcolm knew that it was a dinosaur because he had seen them before at Jurassic Park. Then he called Levine and he wasnt home. Then he got in contacted with Doctor Thorne, who was making some special field vehicles for Levine. Thorne also didnt know were Levine was. Both of them and two of Levine students from school, Kelly and Arby went over to Levines apartment. There he found a huge map on his wall and they figured out that Levine was on Isla Sorna. They figured it out by looking up old files on Site B on his computer, that he bought form InGen. They then decided to go to that island and get him. They then called Sarah Harding and asked her if she wanted to go and she said that she would think about it. Once on the island they unpacked the specially made trailer and the Explorer from the huge steel containers that the helicopter had brought to the island. They both ran off of electric and ...

Use of Hopfield Networks as Analytic Tools

Use of Hopfield Networks as Analytic Tools Through the study of Sheikhan Hemmati (2011), it is seen that Hopfield networks act as a means for researchers to understand the processing and retrieval of memory in human beings (Sheikhan Hemmati, 2011).Advertising We will write a custom research paper sample on Use of Hopfield Networks as Analytic Tools specifically for you for only $16.05 $11/page Learn More The reason behind this is connected to the concept of memory vectors which are utilized as a way in which patterns are conceptualized, retrieved then subsequently pieced back together in order to create a somewhat synonymous pattern as its original conception. As an analytic tool, this helps researchers to better understand how memories are retrieved and then combined to create the thoughts and actions that we have at the present. What must be understood is that while cognitive psychology has enabled researchers and students alike to understand how memory works, there is still a gap in knowledge in being able to see so to speak how memories from a variety of different memory vectors are combined into what we know as memory. This is where Hopfield networks come into play, they are designed as an artificial neural network from which the input of content utilizing a variety of learning rules are implemented so as to understand how they would be applicable in a human neural network. Through this, psychologists are better able to understand the processes that go into learning and potentially discover new methods that could help to resolve learning impairments or even improve the process of learning as a whole. One possible theoretical approach to this can be seen in the study of Hsu (2012) which explained that as analytical tool, the Hopfield network can actually be considered an early start to the development of artificial learning networks which could potentially create an A.I. (Artificial Intelligence) (Hsu, 2012).Advertising Looking for research paper on psychology? Le t's see if we can help you! Get your first paper with 15% OFF Learn More Hsu (2012) explains this by stating that over time the processes that go into creation of computers will increasingly attempt to replicate the efficiency and learning ability of the human mind. As such, understanding how learning actually works is the first step to creating an artificial neural network that is independent from outside input and can merely learn on its own. Other potential applications of the network can be seen in the study of Menezes Monteiro (2011) which proposed that the discrete-time neural network proposed by Hopfield can be used for storing and recognizing binary patterns (Menezes Monteiro, 2011). Through their study, which investigated the removal of simulated neurons within the network, helps to show how there is the potential for the use of the Hopfield model to potentially help in the rehabilitation of individuals that suffer from memory loss as a direct result of da mage to some part of their brain which would impact either their short term or long term memory. For example, one model for understanding the processes involved in working memory is the Baddeley and Hitch (1974) multi-component model which states that working memory operates via a system of slave systems and a central controller which supervises the transmission and coordination of information (RepovÃ…   Baddeley, 2006). Despite understanding how memory works and is retrieved to a certain extent, it is still unknown what processes go into combining it to create what we know of as working memory. The Hopfield model helps to resolve this issue by presenting a â€Å"rough sketch† of what we perceive of as a model of a neural network in order to understand that processes may go into the individual memory vectors resulting in present day learning mechanisms.Advertising We will write a custom research paper sample on Use of Hopfield Networks as Analytic Tools specifically for you for only $16.05 $11/page Learn More One example of this process at work can be seen in the astronomical charts and models that are used to represent the present day solar system. While they are not 100% accurate in terms of correctly showing how the planets move, they do give a rough approximation of positions and processes thereby enabling a better understanding of the process as a whole. The same can be said of Hopfield networks wherein researchers are aware that they are not a 100% accurate method of understanding the complexities of neural networks and the processes that go into them. However, by gaining a rough idea of how such mechanisms work in the first place, researchers are able to know how they work and through such discoveries enable the creation of more accurate models and theories regarding the means and methods of human learning and memory creation. Inherent shortcomings The inherent shortcoming of such a network though lies in the fact that intrusions can, and often do occur, and, as a result, it cannot really be stated that Hopfield networks act as a mirror for the associative memory mechanisms of the human brain. On the other hand, studies such as those by Liu, Huang Chen (2012) attempt to explain such intrusions by stating that even in human memory, the retrieval mechanisms are not 100% accurate with the brain filling in so to speak the apparent gaps that occur. It is this filling in process that Liu, Huang Chen (2012) associates with the intrusions within Hopfield networks as the network attempts to conceptualize the initial image it had to work with the jumble that came about as it was processes through the network (Liu, Huang Chen, 2012).Advertising Looking for research paper on psychology? Let's see if we can help you! Get your first paper with 15% OFF Learn More The end result is a kind of filled in image that is based on the network trying to fill in the gaps with what information it had available. Thus, for (Martinelli, 2010), the Hopfield network is an accurate representation of a primitive associative memory network (Martinelli, 2010). However, it should also be noted that the degradation of information in the Hopfield network is also explained instances such as the Ericsson and Kintsch (1995) model which explains that all individuals utilize skilled memory in everyday tasks however most these memories are stored in long term memory and then subsequently retrieved through various forms of retrieval mechanisms (Martinelli, 2010). When these memories are retrieved there is no degradation and in fact the act of daily retrieval actually reinforces the memory. The Hebb learning rule attempts to explain this by stating the learning (as seen in humans or in the case of the Hopfield network) occurs as a direct result of weights strengthening th e retrieval mechanism. Thus, over time and repetition, the accuracy of a retrieved image gets better. Such is the case when it comes to Hopfield networks wherein daily retrieval of the memory does result in a more accurate image. Hopfield Networks and Learned Behavior Based on the article Extended Hopfield Network for Sequence Learning: Application to Gesture Recognition by Maurer et al., it can be seen that Hopfield networks can be utilized in order to model what is known as learned action. It is described as sets of motion that are learned based on observation and mimicry (i.e. shooting a basketball, swinging a baseball bat etc.). However, it must be questioned whether Hopfield networks are an accurate representation of the brain’s learning behavior or if it is merely a vague representation of how information is accurately brought up and translated into action. It is often the case that people associate memories as a collection of neurons and synapses working in conjunction with each other in order to record pertinent information on a daily basis yet few think of the way in which the concept of memory can be comparable to that of a library where information is stored, recorded and categorized based on its type and attributes. In the case of learned behavior, the application of Hopfield model as a means of understanding how the brain works is applicable if we assume that memory vectors within the human mind exist which result in the retrieval mechanism of memories. For example, a memory vector can be considered as a node which connects other memories together that is utilized by a central controller in order to create a distinct action or image. The action of turning on a faucet can thus consist of several nodes where aspects related to vision, mechanical action and grasping are derived and combined by the central controller in order to create the motion of turning on a faucet. This can be seen in the case of the Hopfield networks wherein multiple node s act in order to reproduce the information/image that was inputted into them. One way in which the Hopfield model, as an accurate model for examining the learning behavior of the human brain, has attempted to be proven can be seen in studies as those by Popescu et al., (2012) which explain that the memory models such as those by Ericsson and Kintsch show that it would be impossible to hold so to speak all memories within our working memory rather what occurs is that individuals hold only a few concepts related to a task within their working memory and then use those as indicators to retrieve the information from long term memory (Popescu et al., 2012). As such, the way in which nodes within the Hopfield model work are the same as how memory retrieval mechanisms work in real life wherein what you consider as learned behavior is the result of combined information from various nodes which in turn result in memory that is being sought. Unfortunately, studies such as those by Liu et al. (2011) indicate that while the Hopfield model may seem to be an accurate model of how learning mechanisms work over time, it still fails to properly show the connection between storage and retrieval. What you must understand is that the input mechanism of the Hopfield network is not the same as what is present in the human mind. The nodes in the model essentially receive information from different sources and attempt to create an approximate â€Å"whole† from the collected information. This action does not explain how the memory vectors within the human mind know how to store the correct kind of information (Liu et al., 2011). Despite this, Liu et al. (2011) does state that Hopfield networks are capable of helping us understand how memories are learned and reinforced but not necessarily the mechanisms that enable them to be stored in a variety of possible storage locations. Reference List HSU, W. (2012). Application of competitive Hopfield neural network to brain-computer in terface systems. International Journal Of Neural Systems, 22(1), 51-62. Liu, Y., Huang, Z., Chen, L. (2012). Almost periodic solution of impulsive Hopfield neural networks with finite distributed delays. Neural Computing Applications,  21(5), 821-831. Liu, W., Fu, C., Hu, H. (2011). Global exponential stability of a class of Hopfield neural networks with delays. Neural Computing Applications, 20(8), 1205-1209. Martinelli, G. (2010). A Hopfield neural network approach to decentralized self- synchronizing sensor networks. Neural Computing Applications, 19(7), 987-996 Menezes, R. R., Monteiro, L. L. (2011). Synaptic compensation on Hopfield network: implications for memory rehabilitation. Neural Computing Applications, 20(5), 753-757 Popescu, D., Amza, C., LÄÆ'ptoiu, D., Amza, G. (2012). Competitive Hopfield Neural Network Model for Evaluating Pedicle Screw Placement Accuracy. Strojniski  Vestnik / Journal Of Mechanical Engineering, 58(9), 509-516. RepovÃ…  , G. G., Badde ley, A. A. (2006). The multi-component model of working memory: Explorations in experimental cognitive psychology. Neuroscience,  139(1), 5-21. Sheikhan, M. M., Hemmati, E. E. (2011). High reliable disjoint path set selection in mobile ad-hoc network using Hopfield neural network. IET Communications,  5(11), 1566-1576.

Can Christians disagree on a moral issue Essay Example | Topics and Well Written Essays - 750 words

Can Christians disagree on a moral issue - Essay Example Moral issues can be created when an individual, a community or a firm is not in control of all the factors that influence the choices that they make. For example, there are differences in moral values and norms accepted by the individuals who are practicing different religions. Moral issues arise as the values and norms accepted by the individuals do not comply with each other. However, an individual who is devoted to a specific religion cannot force the others in the world to accept one set of values and norms accepted by that specific religion. Therefore, Christianity which is a specific religion does not act as a barrier to arising moral issues in the society. Clearly, two Christians can have different opinions on a given moral issue. Moral code indicates that individuals have a larger role to play in the society than just chasing dollars and cents. There are various moral issues that are often viewed as controversial by different people. The main reason why people tend to disagre e over certain moral issues is that they have different perceptions about their worldview. Even devoted Christians can disagree on different moral issues and there are several reasons why this trend is common because Christianity fails to create perspective that can be universally held. A devoted Christian is a person who is devoted to the teaching of Jesus Christ as written in the Bible. In my view the religious faith can discourage critical thinking on a specific moral issue. There are many disagreements regarding what is written in the Bible and who wrote them. Therefore, even the most faithful Christians can have different perception on specific moral issues. Wise people often think out of the box and view different moral issues in an analytical perspective. For instance, the same bible can be used by two Christians to defend or condemn the practice certain moral issues as they believe their own understanding on gospels as the absolute â€Å"truth.† However, is it rationa l to denounce perceptions of the other people just because they are different? No, it is irrational. Some devoted Christians may view critical thinking as inappropriate and readily condemn other people’s views. Therefore, two individuals can have different opinions about a specific moral issue. Some other Christians who are more open-minded can look into the same moral issue from different perspectives and consider the possibility of others’ understanding also being acceptable. In reality, different individuals in the society are enslaved by different perceptions. These perceptions are associated with the different levels of individual intellectual capacities, different enduring social experiences and differential exposure to cultural values and norms. Individuals can view their own perception as the â€Å"only† truth and haste to judge other human beings in the society. Therefore disagreements upon specific moral issues can arise between two different individua ls regardless of the fact that they are both devoted to Christianity and are educated. As a point of departure, it is important to note that each person has his or her own opinions. It is important to acknowledge the fact that having different opinions is â€Å"not wrong† but is inevitable. The strategy to deal with the different

Response Structure Essay Example | Topics and Well Written Essays - 1000 words

Response Structure - Essay Example Road incidents cause congestion on highways and freeways. Because of the importance of traffic incidents, crisis management providers of service, and law enforcement agencies are working towards â€Å"incident management† in many cities of United State. It can be defined as a planned, organized, and methodical utilization of institutional, technical, scientific, industrial, perfunctory resources to lessen the time and shock of incidents, and enhance the safety of victims and motorists and car riders on the highways in case of road incidents. (Balke, K.N. Fenno, D.W., Ullman, B. (November 2002)). Intensity of incident management differs considerably from one state to another. In many areas, an intricate traffic control system that make use of video observation cameras and other automatic accident exposure systems to watch the freeways and also to counter possible incidents situations. Other areas like Texas use service patrols or motorist supportive patrols that go about the freeways and monitor incidents and give adequate help to vehicles or put immobilized vehicles off the roads. (Balke, K.N. Fenno, D.W., Ullman, B. (November 2002). Evaluation of the incident management system is the measurement of own incident management system to the set goals or objectives. By the use of performance evaluation, agencies can achieve the following: The Coordinator of Texas State Incident Management Team, Bob Koenig, believes that to increase the State’s potential for managing incidents in Texas should be guided by multiple periods of operations, by using various resources and also by following several authorities. He works for the missions for Hurricane response. (Koenig, B. (2010) In many areas all cross the United States of America, different societies work for different parts of the process of incident management. Their sole objective is protecting people and working for their betterment. (Balke, K.N. Fenno,